Disease screening models have been hindered by limited interpretability and subpar performance, but a new approach called EviScreen is poised to change this. By leveraging evidential reasoning, EviScreen enhances the transparency of screening results for medical images, allowing for more effective referencing of historical cases and providing clear reasoning pathways. This advancement has significant implications for clinical practice, as it enables earlier detection and more timely intervention. The introduction of EviScreen addresses a critical gap in current screening models, which often fail to provide transparent mechanisms for referencing prior cases or explaining their decision-making processes1. As a result, EviScreen has the potential to improve patient outcomes and streamline clinical decision-making. The development of more interpretable and effective screening models like EviScreen matters to practitioners because it can lead to better disease diagnosis and treatment, ultimately saving lives.