The US Department of Health and Human Services proposes a major overhaul of biomedical research by leveraging artificial intelligence to accelerate disease breakthroughs. The ARPA-H program aims to establish an AI-enabled ecosystem that facilitates seamless data exchange and collaboration among researchers, thereby reducing the time to achieve medical breakthroughs by a factor of ten. This initiative seeks to tackle complex diseases and chronic illnesses that currently require years of research to yield significant findings. By harnessing the power of AI, the department hopes to create a more efficient and effective research framework1. The proposed restructuring has significant implications for the biomedical research community, as it promises to usher in a new era of rapid discovery and innovation. So what this means for practitioners is that they can expect a significant shift in the way biomedical research is conducted, with AI playing a central role in driving progress and saving lives.