A single click can be all it takes to bring down an entire organization, with most major breaches originating from a lone employee falling victim to a cleverly crafted email. The increasing use of artificial intelligence by hackers has made it even more challenging to detect these initial infections, dubbed "Patient Zero" incidents. If a laptop is compromised, the potential for a full-scale shutdown is very real, and having a plan in place to mitigate this risk is crucial. State-aligned threat activity has elevated the stakes, transforming what was once a purely criminal concern into a geopolitical issue with far-reaching implications1. This shift underscores the need for organizations to reassess their cybersecurity strategies and develop effective response plans to counter these sophisticated threats. So what matters to practitioners is that they must now consider the potential for a single click to have catastrophic, organization-wide consequences, extending beyond the immediate target.