The US Department of Energy has chosen 278 projects to receive funding under its Genesis Mission initiative, which focuses on leveraging artificial intelligence to accelerate scientific discovery in fields such as energy and national security1. These projects, led by a diverse range of organizations including national laboratories, universities, and companies, will have access to the Genesis Mission Platform, a tool designed to facilitate AI-enabled scientific workflows. Research areas covered by the selected projects include nuclear energy, critical minerals, and commercial fusion energy. By supporting the development of AI-driven scientific workflows, the Department of Energy aims to drive innovation and breakthroughs in these critical fields. The selection of these projects marks a significant step forward in the Genesis Mission, which has the potential to revolutionize the way scientific research is conducted. This matters to practitioners because it signals a major investment in the use of AI to drive scientific progress, potentially leading to new breakthroughs and discoveries.