A recent breakthrough in autonomous zero-day discovery has uncovered over 14,000 previously unknown vulnerabilities in open-source software, leveraging a system called NOVA developed by Frontier AI. This significant finding has far-reaching implications for the security of the open-source software supply chain. The discovery was made possible by the industrialization of zero-day discovery, allowing for the identification of vulnerabilities at an unprecedented scale. The fact that these vulnerabilities can be exploited before patches are available1 puts defenders at a significant disadvantage, highlighting the need for proactive measures to stay ahead of potential threats. The use of AI in vulnerability discovery is revolutionizing the field, enabling the detection of weaknesses that may have gone unnoticed by human researchers. This development matters to security practitioners because it underscores the importance of staying vigilant and adapting to the rapidly changing threat landscape, where zero-day exploits can be used to devastating effect.